Oligonucleotide conjugates for therapeutic applications
نویسندگان
چکیده
منابع مشابه
Synthesis of oligonucleotide-peptide conjugates for biomedical and technological applications.
Oligonucleotide-peptide conjugates have attracted considerable interest especially for biomedical uses. In the first part of this chapter, we describe protocols for the stepwise synthesis of oligonucleotides carrying peptide sequences at the 3'-end on a single support. The resulting oligonucleotide-peptide conjugates may be used as exogenous effectors for the specific control of gene expression...
متن کاملSpecial Issue "Synthesis and Applications of Oligonucleotide Conjugates".
The underlying idea of oligonucleotide conjugates is to provide oligonucleotide with some novel property [...].
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Although peptide-oligonucleotide conjugates (POCs) are well-known for nucleic acids delivery and therapy, reports on internal attachment of peptides to oligonucleotides are limited in number. To develop a convenient route for preparation of internally labeled POCs with improved biomedical properties, peptides were introduced into oligonucleotides via a 2'-alkyne-2'-amino-LNA scaffold. Derivativ...
متن کاملPreparation of pure oligonucleotide-alkaline phosphatase conjugates.
The utility and sensitivity of enzyme-labeled oligonucleotide probes have been described (1, 2). However, most methods used for their preparation require the use of extensive column chromatography, polyacrylamide gel electrophoresis, or high-pressure liquid chromatography to yield a pure product (3-5). Commercial kits offer a simple alternative but typically 1) are expensive, 2) utilize freeze ...
متن کاملEvaluating the Specificity of Antisense Oligonucleotide Conjugates
Antisense oligonucleotides are potentially powerful tools for selective control of cellular and viral gene expression. Crucial to successful application of this approach is the specificity of the oligonucleotide for the chosen RNA target. Here we apply DNA array technology to examine the specificity of antisense oligonucleotide treatments. The molecules used in these studies consisted of phosph...
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ژورنال
عنوان ژورنال: Therapeutic Delivery
سال: 2013
ISSN: 2041-5990,2041-6008
DOI: 10.4155/tde.13.47